Nkọwa dị mkpirikpi:
Nọmba CAS: 54965-21-8
Usoro ihe omimi: C12H15N3O2S
arọ molekụla: 265.333
Ọdịdị kemịkal:
Nkọwa
Albendazole (ALBENZA) bụ ọgwụ anthelmintic sara mbara nke a na-eji ọnụ. Mbadamba ụrọ Albendazole a na-ata ata gụnyere n'ime World Health Organisation (WHO) ndepụta ọgwụ ndị dị mkpa dị ka ọgwụ anthelminth nke eriri afọ na ọgwụ antifilarial. Ọ bụ SmithKline Animal Health Laboratories mepụtara mbadamba nkume Albendazole wee kwado ya na US Food and Drug Administration (FDA) na 1996.
Albendazole nwere ikike igbu kpamkpam nsen nke whipworm na hookworm yana igbu akụkụ nke akwa Ascaris; ọ nwekwara ike ikpochapụ ụdị nematodes dị iche iche na-efe efe n'ime ahụ anụmanụ, na-enwekwa mmetụta na iwepụ ma ọ bụ gbuo tapeworms na cysticerci ozugbo. Ya mere, ọ bara uru na ọgwụgwọ hydatid na usoro ụjọ ahụ (cysticercosis) nke kpatara ọrịa anụ ezi anụ ezi, nakwa na ọgwụgwọ hookworm, roundworm, pinworm, nematode trichinella, tapeworm, whipworm na stercoralis nematode.
Pharmacodynamics
Albendazole bụ ụdị ọgwụ benzimidazole. A na-emegharị ya ngwa ngwa na vivo n'ime sulfoxide, sulfone na 2-polyamine sulfone mmanya. Ọ nwere ike na-ahọrọ na nke na-agbanweghi agbanwe na-egbochi nnabata glucose nke nematodes nke eriri afọ, si otú a na-ebute mbelata glycogen endogenous nke ikpuru; N'otu oge ahụ, ọ na-egbochi ọrụ fumarate reductase, ma si otú a na-egbochi ọgbọ nke adenosine triphosphate, n'ikpeazụ na-akpata ọnwụ nke nje.
Dị ka mebendazole, site n'ime ka denaturation nke cytoplasmic microtubules nke eriri afọ nje na-ejikọta na tubulin, ọ na-eme ka mkpọchi nke intracellular iga, na-eme ka mkpokọta Golgi endocrine ụmụ irighiri; cytoplasm na-eji nke nta nke nta gbazee, na-akpata ọnwụ ikpeazụ nke nje.
Ngwaahịa a nwere ike igbu akwa nkoworm kpamkpam, akwa pinworm, akwa ajị anụ, akwa tapeworm na akwa akwa cysticercosis wee gbuo akwa Ascaris.
Ejikarị
Albendazole bụ ọgwụ a na-eji agwọ ọrịa nje ndị nje na-akpata. Enwere ike inye ya ọgwụgwọ ọrịa ụbụrụ na-adịghị ahụkebe (neurocysticercosis) ma ọ bụ enwere ike inye ya iji gwọọ ọrịa nje na-ebute afọ ọsịsa dị mkpa (microsporidiosis).
Iji ụlọ ọgwụ
Albendazole nwere ọtụtụ ọrụ dị iche iche megide nematodes nsia na cestodes, yana flukes imeju Opisthorchis sinensis, Opisthorchis viverrini, na Clonorchis sinensis. Ejikwa ya nke ọma megide Giardia lamblia. A na-eji ya n'ụwa niile maka ọgwụgwọ ọrịa intestinalnematode. Ọ dị irè dị ka ọgwụgwọ otu dose maka ascariasis, New na Old World hookworm ọrịa, na trichuriasis. Usoro ọgwụgwọ ọtụtụ dose na albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, na ọrịa hydatid. Ịdị irè nke albendazole megidetapeworms (cestodes) na-agbanwekarị ma na-enwechaghị mmetụta. Ọ dịkwa irè n'ịgwọ ọrịa cerebral na spinal neurocysticercosis, karịsịa mgbe a na-enye ya na dexamethasone. A na-atụ aro Albendazole maka ọgwụgwọ gnathostomiasis.
