Nkọwa dị mkpirikpi:
Nọmba CAS:590-63-6
Usoro ihe omimi:C7H17ClN2O2
arọ molekụla:196.68
Ọdịdị kemịkal:
| Ozi bụ isi | |
| Aha ngwaahịa | Betanechol |
| Ọkwa | Ọkwa ọgwụ |
| Ọdịdị | ọcha ntụ ntụ |
| Nyocha | 95% |
| Ndụ nchekwa | afọ 2 |
| Nkwakọ ngwaahịa | 25kg / agba |
| Ọnọdụ | Ebe dị jụụ na nkụ |
Nkọwa
Bethanechol bụ ester sịntetịt nke structurally na pharmacologically metụtara acetylcholine. A na-eji nwayọọ nwayọọ hydrolyzed muscarinic agonist na-enweghị mmetụta nicotinic, a na-ejikarị bethanechol na-amụba ụda anụ ahụ dị nro, dị ka na traktị GI na-esote ịwa ahụ afọ ma ọ bụ na-ejigide urinary na enweghị nkwụsị. Ọ nwere ike ịkpata hypotension, mgbanwe ọnụego obi, na spasms nke bronchi.
Bethanechol bụ agonist nke muscarinic acetylcholine receptors na IC50 ụkpụrụ nke 1,837, 25, 631, 317, na 393 μM maka M1-5, n'otu n'otu, na radioligand njide assay site na iji sel CHO na-egosipụta mmadụ anabata. Ọ na-egbochi mmụba mgbasa ozi M2 na cyclic AMP nke isoproterenol kpatara na obere eriri afọ Guinea pig dịpụrụ adịpụ (IC50 = 127 μM). Bethanechol na-abawanye ụda basal nke ureter intravesical porcine dịpụrụ adịpụ (EC50 = 4.27 μM). Ọ na-ebutekwa nzuzo mmiri na ileum, duodenum, na jejunum nke oke aneshetized mgbe a na-enye ya na dose nke 60 μg / kg. A na-eji usoro ndị nwere bethanechol mee ka mmamịrị mụbaa ma melite ụda akwara dị nro na eriri afọ.
Iji ụlọ ọgwụ
Isi ojiji nke bethanechol chloride bụ enyemaka nke njide nke urinary na mgbakasị afọ mgbe a wachara ya ahụ. Agaghị ejikwa ya site na intramuscular ma ọ bụ intravenous injection n'ihi ihe egwu dị na oke mkpali cholinergic yana mfu nke nhọrọ nhọrọ. Ejikọtara nchịkwa nke ọma nke ọgwụ ahụ na obere nsi na enweghị mmetụta dị njọ. Ekwesịrị iji Bethanechol chloride mee ihe na-akpachapụ anya ndị ọrịa inasthmatic; mgbe ejiri ya maka glaucoma, ọ na-emepụta isi ọwụwa n'ihu site na mgbochi nke sphinctermuscle na anya na site na spasms muscle ciliary. Ogologo oge ọrụ ya bụ elekere 1.
Ọgwụgwọ na ọgwụgwọ ọrịa anụmanụ
N'ọgwụgwọ ọrịa anụmanụ, a na-eji bethanechol eme ihe n'ụzọ bụ isi iji kpalite mkpụkọ eriri afọ na obere anụmanụ. Enwere ike iji ya dị ka ihe na-akpali akpali nke esophageal ma ọ bụ izugbe GI, ọ bụ ezie na metoclopramide na / ma ọ bụ neostigmine ejirila ya dochie ya maka ojiji ndị a.
