环维生物

Ụlọ ọrụ HUANWEI BIOTECH

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Cefazolin sodium nnu

Nkọwa dị mkpirikpi:

Nọmba CAS: 27164-46-1

Usoro ihe omimi: C14H15N8NaO4S3

arọ molekụla: 478.5

Ọdịdị kemịkal:


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  • Nkọwa ngwaahịa

    Mkpado ngwaahịa

    Ozi bụ isi
    Aha ngwaahịa Cefazolin sodium nnu
    CAS Mba. 27164-46-1
    Ọdịdị Uzuzu crystalline ọcha ruo na-acha ọcha
    Ọkwa Ọkwa Pharma
    Nchekwa Debe n'ebe gbara ọchịchịrị, ikuku na-adịghị mma, 2-8 Celsius
    Ndụ shelf afọ 2
    Nkwụsi ike Kwụsie ike, mana ọ nwere ike ịdị ọkụ - chekwaa n'ọnọdụ dị mma. Enwere ike ịcha agba mgbe mkpughe na ìhè - chekwaa n'ọchịchịrị. Ekwekọrịtaghị na ndị ọrụ oxidizing siri ike.
    ngwugwu 25kg/Drum

    Nkọwa ngwaahịa

    Ọgwụ nje sịntetik nke ọkara nwere cephalosporins n'ime molecule nke cephalosporins. Atụgharịrị dị ka Xianfeng mycin. bụ nke β-Ọgwụ nje Lactam, ee β- Ihe ndị sitere na 7-aminocephalosporanic acid (7-ACA) na ọgwụ nje lactam nwere usoro nje bacteria ndị yiri ya. Ụdị ọgwụ a nwere ike imebi mgbidi cell nke nje bacteria ma gbuo ha n'oge ọmụmụ. Ọ nwere mmetụta nhọrọ siri ike na nje bacteria na ọ fọrọ nke nta ka ọ bụrụ ihe na-adịghị egbu egbu nye mmadụ, yana uru dị ka ụdị nje bacteria obosara, mmetụta antibacterial siri ike, iguzogide penicillin enzymes, yana mmeghachi ahụ nfụkasị dị ala ma e jiri ya tụnyere penicillin. Ya mere, ọ bụ ọgwụ nje dị mkpa na-arụ ọrụ dị elu, obere toxicity, yana ngwa ụlọ ọgwụ sara mbara. E mepụtara cephalosporins ọgbọ mbụ na mbụ, na-arụ ọrụ antibacterial siri ike ma e jiri ya tụnyere Chemicalbook, ụdị nje antibacterial dị warara, yana mmetụta nje nje gram dị mma karịa nje bacteria Gram. Mepụtara Staphylococcus aureus β-Lactamase kwụsiri ike ma nwee ike igbochi mmepụta nke nje bacteria na-adịghị mma β-Lactamases anaghị eguzosi ike ma nwee ike imepụta ya site na ọtụtụ nje bacteria Gram negative β- mebiri site na lactamases. Cefazolin sodium bụ cephalosporin ọgbọ mbụ synthetic nke nwere mmetụta antibacterial megide nje gram-positive na gram-adịghị mma. A na-ejikarị ya na-efe efe nke usoro iku ume, usoro urogenital, anụ ahụ dị nro, ọkpụkpụ na nkwonkwo, na tract biliary nke nje bacteria na-enwe mmetụta na-akpata, yana na endocarditis, sepsis, pharyngeal na ntị. Ọ nwere ọrụ siri ike megide nje bacteria gram-positive dị ka Staphylococcus aureus na Streptococcus (ewezuga Enterococcus), ma dị elu karịa ọgbọ nke atọ nke cephalosporins.

    Eji kemịkalụ

    Cefazolin (Ancef, Kefzol) bụ otu n'ime usoro semisyntheticcephalosporins nke arụ ọrụ C-3 acetoxy ejirila heterocycle nwere thiol-ebe a, 5-methyl-2-thio-1,3,4-thiadiazole. Ọ nwekwara ihe na-adịghị ahụkebe tetrazolylacetyl acylating otu. A tọhapụrụ Cefazolin na 1973 dị ka nnu sodium na-agbaze mmiri. Ọ bụ naanị site na nchịkwa parenteral.

    Cefazolin na-enye ọkwa ọbara ọbara dị elu, nkwụsị nke renalclearance na-adị nwayọọ, yana ogologo ndụ ọkara karịa ndị ọzọ ọgbọ nke cephalosporins. Ọ bụ ihe dịka 75% protein jikọtara inplasma, uru dị elu karịa nke ọtụtụ cephalosporins ndị ọzọ. N'oge mbụ na vitro na ọmụmụ ụlọ ọgwụ na-atụ aro na cefazolin na-arụsi ọrụ ike megide gram-negative bacilli mana ọ naghị arụ ọrụ megide Gram-positive cocci karịa ma cephalothin ma ọ bụ cephaloridine. Ọnụọgụ nke thrombophlebitis na-esochi ịgba ntụtụ na mgbu na saịtị intramuscularinjection yiri ka ọ bụ nke kacha ala nke parenteralcephalosporins.


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