Cefoperezone sodium + sulfactam sodium

Nkọwa:
Cefoperazone sodium + sulfactam sodium (1: 1/2: 1) bụ nne na nna na-arụ ọrụ, β-lactamase inhibitor ewepụtara n'oge na-adịbeghị anya dị ka ngwaahịa ngwakọta 1: 1 na cefoperazone. Dị ka clavulanic acid, onye nnọchite mbụ nke ụdị a ka ewebata, sulbactam na-akwalite ịdị irè nke ọgwụ nje β-lactam megide ụdị ndị na-eguzogide ọgwụ.
Ojiji:
Ihe mgbochi β-lactamase nke ọkara synthetic. A na-eji ya na ọgwụ nje β-lactam mee ihe dị ka antibacterial.
Cefoperazone sodium nnu bụ ọgwụ nje cephalosporin maka igbochi rMrp2-mediated [3H] E217βG nnabata na IC50 nke 199 μM. Ebumnuche: Cefoperazone Antibacterial bụ ihe na-adịghị mma, semisynthetic, nke sara mbara, ọgwụ nje cephalosporin parenteral maka nchịkwa intravenous ma ọ bụ intramuscular. Mgbe nchịkwa intravenous nke 2 g nke Cefoperazone gasịrị, ọkwa dị na serum sitere na 202μg/mL ruo 375 μg/mL dabere na oge nchịkwa ọgwụ. Mgbe ịgba ọgwụ mgbochi intramuscular nke 2 g nke Cefoperazone gasịrị, ọkwa ọbara kacha elu bụ 111 μg/mL na awa 1.5. Na awa 12 ka emechara ọgwụ ahụ, ọkwa nke serum ka dị 2 ruo 4 μg / ml. Cefoperazone bụ 90% jikọtara ya na protein serum.