Cefradine

Cefradine (nke a makwaara dị ka cephradine), 7-[D-2-amino-2 (1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- ene-2-carboxylic acid monohydrate (111 bụ ọgwụ nje cephalosporin semi-synthetic. eji ọnụ, intramuscularly, na intravenously. Ọdịdị nke cephradine yiri nke cephalexin, naanị ihe dị iche bụ na mgbanaka nwere akụkụ isii. Cephalexin nwere atọ. Njikọ abụọ na-akpụ usoro aromatic ebe cephradine nwere njikọ abụọ n'otu mgbanaka na-arụ ọrụ antibacterial nke cephradine yiri nke cephalexin^[1].

Ihe atụ1 usoro kemịkalụ nke cefradine;
Cephradine bụ kristal na-acha ọcha ntụ ntụ nwere nha molekụla nke 349.4^[2]. A tụlere njikọ nke cephradine^[3]. Cephradine na-agbaze kpamkpam na ihe mgbaze mmiri. Ọ bụ zwitterion, nwere ma otu amino acid alkaline na otu carboxyl acid. Na pH nke 3-7, cephradine dị ka nnu dị n'ime^[4]. Cephradine kwụsiri ike maka 24 hr na 25 "n'ime pH nke 2-8. Ebe ọ bụ na ọ kwụsiri ike na mgbasa ozi acidic, enwere obere mfu nke ọrụ na mmiri gastric; mfu nke na-erughị 7% ka akọpụtala.^[5].
Cephradine na-ejikọta ya na protein serum nke mmadụ. Ọgwụ ahụ erughị 20% jikọtara ya na protein serum^[4]. Na mkpokọta serum nke 10-12 pg / ml, 6% nke mkpokọta ọgwụ dị na mgbagwoju protein. Ọmụmụ ihe ọzọ^[6]chọpụtara na na mkpokọta mkpokọta 10 pg / ml, 28% nke ọgwụ ahụ nọ na steeti protein jikọtara; na mkpokọta mkpokọta 100 pg / ml, 30% nke ọgwụ ahụ nọ na steeti protein. Ọmụmụ ihe a gosikwara na mgbakwunye nke serum na cephradine belatara ọrụ ọgwụ nje. Ọmụmụ ihe ọzọ^[2]gosiri na njikọ protein nke cephradine dịgasị iche site na 8 ruo 20%, dabere na ntinye ọgwụ. Agbanyeghị, ọmụmụ nke Gadebusch et al.^[5]Ahụghị mgbanwe ọ bụla na MIC nke cephradine n'ebe Staphylococcus aureus ma ọ bụ Escherichia coli gasịrị mgbe agbakwunyere ọbara mmadụ.