Nkọwa dị mkpirikpi:
Nọmba CAS: 1264-72-8
Usoro ihe omimi: 2 (C52H98N16O13).5 (H2SO4)
arọ molekụla: 2801.27
Ọdịdị kemịkal:
| Ozi bụ isi | |
| Aha ngwaahịa | Colistin sulfate |
| Ọkwa | Nri ọkwa |
| Ọdịdị | White ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha, hygroscopic ntụ ntụ |
| Nyocha | 99% |
| Ndụ nchekwa | afọ 2 |
| Nkwakọ ngwaahịa | 20kg / katọn 20kg / drum |
| Ọnọdụ | Na-echekwa na -20 ℃ maka otu afọ(Ntụ ntụ) |
Nkọwa nke ngwaahịa
Colistin bụ cyclic cationic decapeptide jikọtara ya na agbụ akụkụ abụba abụba, ọ bụ nke otu peptides nje na-egbochi nje nje a haziri ahazi. Colistin sulfate bụ ọgwụ nje polypeptide nke na-egbochi nje bacteria gram-adịghị mma site na ijikọ lipopolysaccharides na phospholipids na mpụta cell akpụkpọ anụ nke gram-adịghị mma.
Colistin sulfate, nke a makwaara dị ka colistin sulfate, Christian (Colistin), Polymyxin E (Polymyxin E), antiphytin, ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ntụ ntụ, enweghị isi, mmiri uto uto, dị mfe soluble na mmiri, ntakịrị soluble na methanol, ethanol, ọ fọrọ nke nta ka ọ bụrụ ihe na-adịghị ike. acetone, ether, alkali free soluble na mmiri. Stable na PH3-7.5 nso. Mycolistin sulfate bụ Bacillus polymyxoides na-emepụta, nke nwere mmetụta antibacterial siri ike na nje gram-adịghị mma. A na-eji ya agwọ ọrịa eriri afọ nke nje bacteria gram-adịghị mma kpatara, a na-ejikwa ya dị ka ihe mgbakwunye nri nwere mmetụta na-akwalite uto doro anya. Nchikota nke mmetụta sulfadiazine ka mma.
Ọrụ nke ngwaahịa
Colistin sulfate granules kwalitere na nkwụsi ike nke ike na nri ma na-egosipụta oke solubility n'agbanyeghị na a na-emepụta ha na-ejighi ihe ọ bụla dị oké ọnụ ahịa ma ọ bụ ngwá ọrụ pụrụ iche. Kpọmkwem, colistin sulfate granules mejupụtara nnoo colistin sulfate na inwe urughuru diameters nke 150 ka 1500m, a kpọmkwem elu ebe 40 ka 500 cm2 / g, a wetting oge nke 5 nkeji ma ọ bụ n'okpuru na a mmiri ọdịnaya nke 10 % ma ọ bụ n'okpuru.
Pharmacodynamics
Colistin bụ ọgwụ nje polymyxin. Polymyxins bụ cationic polypeptides nke na-akpaghasị akpụkpọ ahụ nke nje bacteria site na usoro yiri ncha. Site na mmepe nke ihe ndị na-egbu egbu dị obere, dị ka penicillins na cephalosporins, a na-ahapụkarị ojiji parenteral polymyxin, ma e wezụga ọgwụgwọ nke ọrịa akpa ume na-eguzogide ọgwụ na ndị ọrịa nwere cystic fibrosis.
