Nkọwa dị mkpirikpi:
Nọmba CAS: 55268-74-1
Usoro ihe omimi:C19H24N2O2
arọ molekụla: 312.41
Ọdịdị kemịkal:
| Ozi bụ isi | |
| Aha ngwaahịa | Praziquantel |
| Ọkwa | Ọkwa ọgwụ |
| Ọdịdị | Ọ bụ ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ ọcha crystalline ntụ ntụ |
| Nyocha | 99% |
| Ndụ nchekwa | afọ 2 |
| Nkwakọ ngwaahịa | 25kg / agba |
| Njirimara | Na-agbaze kpamkpam na ethanol ma ọ bụ dichloromethane. Na-agbaze ntakịrị na mmiri |
| Ọnọdụ | E mechiri ya na nkụ, chekwaa na friza, n'okpuru -20 Celsius |
Nkọwa
Praziquantel (PZQ) bụ ihe ewepụtara isoquinoline nwere ọtụtụ ọrụ ndu nke achọtara na levo enantiomer. Ngwakọta ahụ enweghị ọrụ megide nematodes, mana ọ na-arụ ọrụ nke ọma megide cestodes na trematodes.
Pharmacology na usoro nke ime ihe
Praziquantel bụ ogige pyrazinoquinoline emebere maka ọgwụgwọ schistosomiasis mana achọpụtala na ọ nwere ụdị ọrụ anthelminthic dị iche iche. Praziquantel bụ onye agbụrụ mana R (+) enantiomer bụ naanị maka ọrụ mgbochi parasitic ya. Ọ na-arụ ọrụ megide trematodes (ụdị Schistosoma niile na-ebute mmadụ, Paragonimus westermani, na Clonorchis sinensis) na cestodes (Taenia saginata, Taenia solium, Hymenolepis nana na Diphyllobothrium latum).
A maghị nke ọma usoro nke praziquantel. Schistosomes na-ewere ọgwụ ahụ ngwa ngwa. Ịṅụ ọgwụ ọjọọ na-esochi ya ozugbo site n'ịbawanye ọrụ muscular nke na-aga n'ihu na mkpụkọ tetanic na mkpochapụ nke tegument parasaiti.
A na-eche na mmetụta muscular nke ọgwụ ahụ bụ maka ngbanwe nke nje nje site na veins mesenteric na imeju na vivo. Otú ọ dị, schistosomicides a maara nke ọma na-egosipụtakwa mgbanwe ime imeju ma nwee ike ọ gaghị enye ozi ọ bụla akọwapụtara nke usoro ọgwụ ahụ. Nchọpụta nnwale na nso nso a na-atụ aro na mmetụta antischistosomal nke ọgwụ na-emetụta mmetụta ya na tegument kama na musculature.
Mmetụta ọgwụ ọzọ nke ọgwụ na-agụnye mmụba nke membrane permeability na cations, karịsịa calcium.
Otú ọ dị, ọrụ nke mmetụta a na ihe onwunwe anthelminthic nke ọgwụ ahụ amabeghị.
Ngwa
Ọ bụ ụdị ọgwụ mgbochi ọrịa parasitic nke sara mbara. Enwere ike iji ya maka ọgwụgwọ na mgbochi nke schistosomiasis, cysticercosis, paragonimiasis, ọrịa hydatid, fasciolopsiasis, ọrịa hydatid, na ọrịa worm.
Enwere ike iji ya dị ka anthelmintic ma dị irè n'ịgwọ nematodes eriri afọ anụmanụ. Enwere ike ịgwakọta ya na nri maka ngwa.
Ngwaahịa a bụ ụdị ọgwụ anthelmintic dị irè n'ịgwọ Schistosoma japonicum, Schistosoma mansoni na Schistosoma haematobium, Clonorchis sinensis, Paragonimus westermani, fasciolopsis buski, tapeworms na cysticercosis. Ọ nwere mmetụta igbu mmadụ siri ike na tapeworm ma bụrụkwa nke kacha arụ ọrụ ugbu a n'etiti ọgwụ mgbochi schistosomiasis.
Ọ bụ ụdị ọgwụ anthelmintics a na-ejikarị agwọ ọrịa schistosomiasis. Enwere ike iji ya gwọọ Fahrenheit schistosomiasis, taeniasis, paragonimiasis, na cysticercosis.
