Nkọwa dị mkpirikpi:
Nọmba CAS:51322-75-9
Usoro ihe omimi:C9H8ClN5S
arọ molekụla:253.71
Ọdịdị kemịkal:
| Ozi bụ isi | |
| Aha ngwaahịa | Tizanidine |
| Ọkwa | Ọkwa ọgwụ |
| Ọdịdị | Ọcha ntụ ntụ |
| Nyocha | 99% |
| Ndụ nchekwa | afọ 2 |
| Nkwakọ ngwaahịa | 25kg / agba |
| Ọnọdụ | Na-echekwa na -20°C |
Nkọwapụta
Tizanidine bụ imidazoline abụọ nitrogen heterocyclic pentene ewepụtara. Ọdịdị ahụ yiri nke clonidine. Na 1987, e depụtara ya na mbụ na Finland dị ka etiti adrenalin α2 agonist. Ugbu a, a na-eji ya dị ka ihe na-eme ka ahụ ike dị n'etiti na ụlọ ọgwụ. Enwere ike iji ya na-agwọ spasm akwara na-egbu mgbu, dị ka ọrịa n'úkwù n'olu na torticollis. A pụkwara iji ya na-agwọ mgbu mgbu mgbe ịwachara ahụ, dị ka diski herniation na ogbu na nkwonkwo hip. Ọ na-esite na ankylosis nke ọrịa akwara ozi, dị ka multiple sclerosis, myelopathy na-adịghị ala ala, ihe mberede cerebrovascular na wdg.
Ọrụ
A na-eji ya belata mgbakasị ahụ nke anụ ahụ skeletal, spasm muscle na myotonia kpatara ụbụrụ na ọkpụkpụ azụ, ọbara ọgbụgba nke ụbụrụ, encephalitis na otutu sclerosis.
Nkà mmụta ọgwụ
Ọ na-ahọrọ nke ọma na-ebelata ntọhapụ nke amino asịd na-akpali akpali site na interneurons ma na-egbochi usoro synaptik multi synapti metụtara oke ahụ ike. Ngwaahịa a anaghị emetụta nnyefe nke neuromuscular. A nabatara ya nke ọma. Ọ dị irè maka spasms muscle na-egbu mgbu na ankylosis na-adịghị ala ala sitere na ọgidigi azụ na ụbụrụ. Ọ nwere ike belata nguzogide nke mmegharị ahụ, belata spasticity na clonus, ma mee ka mmegharị afọ ofufo dịkwuo ike.
Na-eji
Akpọrọ Tizanidine, ezubere maka iji dị ka ọkọlọtọ ime maka ọnụọgụ Tizanidine site na GC- ma ọ bụ LC-mass spectrometry. Tizanidine nwere ike ịnwe ọgwụgwọ dịka SARS-CoV-2 bụ isi protease inhibitor.
Iji ụlọ ọgwụ
Tizanidine bụ onye na-eme ihe na-eme ihe na-eme ihe na-eme ihe na-eme ka adrenergic α2 agonist nke a na-eji agwọ ọrịa spasticity muscle na-adịghị ala ala, dị ka multiple sclerosis.
Usoro nke ime ihe
Tizanidine bụ analog na-eme ka ahụ dị jụụ na-arụ ọrụ nke ọma nke clonidine nke akwadoro maka iji belata spasticity metụtara mmerụ ahụ ụbụrụ ma ọ bụ ọkpụkpụ azụ. Usoro ya maka ibelata spasticity na-egosi mgbochi presynaptic nke neurons moto naαSaịtị nnabata 2-adrenergic, na-ebelata ntọhapụ nke amino acids na-akpali akpali ma na-egbochi ụzọ ceruleospinal facilitatory, si otú a na-ebute mbelata spasticity. Tizanidine nwere naanị obere akụkụ nke ọgwụ antihypertensive nke clonidine, nke a na-eche na ọ bụ n'ihi omume na obere obere nhọrọ.α2C-adrenoceptors, nke yiri ka ọ na-ahụ maka ọrụ analgesic na antispasmodic. imidazolineα2-agonists (20).
