Nkọwa dị mkpirikpi:
Nọmba CAS: 472-15-1
Usoro ihe omimi:C30H48O3
arọ molekụla: 456.71
Ọdịdị kemịkal:
| Ozi bụ isi | |
| Aha ngwaahịa | Betulinic acid |
| Ọkwa | Ọkwa ọgwụ |
| Ọdịdị | Ọcha ma ọ bụ na-acha ọcha |
| Nyocha | 98% |
| Ndụ nchekwa | afọ 2 |
| Nkwakọ ngwaahịa | 25kg / agba |
| Ọnọdụ | Kwụsie ike, mana chekwaa ya nke ọma. Na-ekwekọghị na ndị ọrụ oxidizing siri ike, calcium gluconate, barbiturates, magnesium sulfate, phenytoin, vitamin B otu sodium. |
Nkọwa
Betulinic acid (472-15-1) bụ Lupane triterpenoid eke sitere na osisi birch ọcha (Betula pubescens). Na-ebute apoptosis n'ụdị ahịrị cell dị iche iche.1 Na-ebute mitochondrial permeability mgbanwe pore oghere.2
Jiri
Betulinic acid bụ triterpenoid pentacyclic eke. Betulinic acid na-egosiputa mgbochi mkpali na mgbochi HIV. Betulinic acid na-ahọrọ akpalite apoptosis n'ime mkpụrụ ndụ tumo site na ịgbalite ụzọ mitochondrial nke apoptosis ozugbo site na p53- na CD95 na-adabere na ya. Betulinic acid na-egosipụtakwa ọrụ agonist TGR5.
A na-eji Betulinic acid (BetA) mee ihe:
1. iji nwalee mmetụta ya dị ka ihe mgbochi nje megide nje Dengue (DENV).
2.dị ka sterol regulatory element-binding protein (SREBP) inhibitor iji mebie metabolism lipid na mmụba nke cell renal cell carcinoma (ccRCRC) sel doro anya.
3.dị ka ọgwụgwọ iji nwalee ihe mgbochi tumor ya maka ịdị ndụ cell na nyocha ọnwụ cell apoptotic n'ọtụtụ ụdị myeloma.
Nnyocha gbasara ọrịa cancer
Ngwakọta a bụ triterpene pentacyclic enwetara site na ụdị Betula na Zizyphus, nke na-egosi cytotoxicity nhọrọ megide mkpụrụ ndụ melanoma mmadụ (Shoeb2006). Ọ na-emepụta ụdị oxygen na-emeghachi omume, na-eme ka MAPK cascade rụọ ọrụ, na-egbochi stopoisomerase I, na-egbochi angiogenesis, na-agbanwe transcriptionalactivators pro-uto, na-eme ka ọrụ aminopeptidase-N na-arụ ọrụ, ma si otú ahụ na-ebute ọrịa cancer (Desai et al. 2008; Fulda 2008).
Ọrụ ndu
Eke triterpenoid nke na-egosiputa mgbochi HIV na antitumor ọrụ. Na-eme ka mmepụta nke ụdị oxygen na-emeghachi omume (ROS) ma mee ka NF-κ B. Na-egosipụta ọrụ agonist TRG5 (EC 50 = 1.04 μ M).
Omume biochem/physiol
Betulinic acid, pentacyclic triterpene, na-ahọrọ nke na-ebute apoptosis n'ime mkpụrụ ndụ etuto site na ịgbalite ụzọ mitochondrial nke apoptosis ozugbo site na usoro p53- na CD95 nwere onwe.
